Stabilized carbonic acid adducts
AssigneeInflamed Pharma GmbH
InventorsBeatrice ENGERT, Christina TOEPEL
Life of this patent
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Abstract
The invention relates to stabilized carbonic acid adducts (SCAA1), (SCAA2), (SCAA3) and (SCAA4) which comprise carbonic acid, at least one amine (AM), optionally, at least one salt (S), and polyvinylpyrrolidone.
Claims18
A stabilized carbonic acid adduct (SCAA1), comprising carbonic acid, at least one amine (AM) and, optionally, at least one salt (S),
- producible according to a method comprising the steps of:
- a) providing a solution (A) comprising at least one solvent and CO2 dissolved in the at least one solvent,
- optionally, b) dissolving a base (BA) other than the amine (AM) in the solution (A) to yield the solution (A1),
- c) dissolving the at least one amine (AM) in the solution (A) or (A1) to yield the solution (B),
- d) freezing the solution yielded after completion of step c),
- e) storing the solution frozen in step d) at −100 to 0° C. for no longer than 4 days,
- g1) adding polyvinylpyrrolidone to the carbonic acid adduct (CAA) yielded in the preceding steps to yield the stabilized carbonic acid adduct (SCAA1),
- wherein the content of CO2 in the solution which is subjected to step d) is at least 6 g/l, preferably at least 7 g/l, more preferably at least 8 g/l, particularly preferably 8.1 g/l to 9.5, and the amine (AM) can also be employed in the form of a salt.
The stabilized carbonic acid adduct (SCAA2), comprising carbonic acid, at least one amine (AM) and, optionally, at least one salt (S),
- producible according to a method comprising the steps of:
- a) providing a solution (A) comprising at least one solvent and CO2 dissolved in the at least one solvent,
- optionally, b) dissolving a base (BA) other than the amine (AM) in the solution (A) to yield the solution (A1),
- c) dissolving the at least one amine (AM) in the solution (A) or (A1) to yield the solution (B),
- g2) adding polyvinylpyrrolidone to the solution (B) yielded in step c) to yield the stabilized carbonic acid adduct (SCAA2).
- wherein the content of CO2 in the solution (B) which is subjected to step c) is at least 10 g/l, preferably at least 12 g/l, more preferably at least 14 g/l, and most preferably at least 14 to 16 g/l, and the amine (AM) can also be employed in the form of a salt.
The stabilized carbonic acid adduct (SCAA3) comprising carbonic acid, at least one amine (AM) and, optionally, at least one salt (S),
- producible according to a method comprising the steps of:
- a) providing a solution (A) comprising at least one solvent and CO2 dissolved in the at least one solvent,
- optionally, b) dissolving a base (BA) other than the amine (AM) in the solution (A) to yield the solution (A1),
- c) dissolving the at least one amine (AM) in the solution (A) or (A1) to yield the solution (B),
- g3) adding polyvinylpyrrolidone to the solution (B) yielded in step c) to yield solution (C),
- h) freezing the solution yielded after completion of step g3),
- j) storing the solution frozen in step h) at −100 to 0° C. for no longer than 4 days, wherein the CO2 content in the solution subjected to step h) is at least 7 g/l, preferably at least 7.5 g/l, and the amine (AM) can also be employed in the form of a salt,
- wherein the steps are carried out in the order listed above:
- a), optionally b), c), g3), h) and j).
The stabilized carbonic acid adduct (SCAA4) comprising carbonic acid, at least one amine (AM) and, optionally, at least one salt (S),
- producible according to a method comprising the steps of:
- a) providing a solution (A) comprising at least one solvent and CO2 dissolved in the at least one solvent,
- optionally, b) dissolving a base (BA) other than the amine (AM) in the solution (A) to yield the solution (A1),
- c) dissolving the at least one amine (AM) in the solution (A) or (A1) to yield the solution (B),
- d) freezing the solution yielded after completion of step c),
- e) storing the solution frozen in step d) at −100 to 0° C. for no longer than 4 days,
- f) drying the solution stored in step e) to yield carbonic acid adduct (CAA),
- k) drying a solution saturated with CO2 comprising the carbonic acid adduct (CAA) from step f) and polyvinylpyrrolidone,
- wherein the CO2 content in the solution subjected to step d) is at least 6 g/l, preferably at least 7 g/l, more preferably at least 8 g/l, particularly preferably 8.1 g/l to 9.5 g/l and the amine (AM) can also be employed in the form of a salt.
Dependencies are inferred from the claim text.