Prebiotic composition for stabilizing a healthy gut microbiota
AssigneeNutriLeads B.V.
InventorsAnnick Marie Esther MERCENIER, Ruud ALBERS
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Abstract
The inventors have discovered that a healthy gut microbiota in a subject may be stabilized by orally administering a prebiotic composition containing at least 0.1% by weight of dry matter of rhamnogalacturonan I (RG-I) polysaccharides having a molecular weight in excess of 10 kDa and having a backbone consisting of galacturonic acid residues and rhamnose residues, said rhamnose residues being contained in alpha(1→4)-galacturonic-alpha(1→2)-rhamnose residues, wherein the molar ratio of galacturonic acid residues to rhamnose residues in the RG-I polysaccharides is within the range of 20:1 to 1:1
Claims14
A non-therapeutic method for stabilizing healthy gut microbiota in a subject by selective prebiotic stimulation of at least one taxonomic group of commensal bacteria, said method comprising the administration a prebiotic composition, wherein the prebiotic composition contains at least 0.1% by weight of dry matter of rhamnogalacturonan I (RG-I) polysaccharides having a molecular weight in excess of 10 kDa and having a backbone consisting of galacturonic acid residues and rhamnose residues, said rhamnose residues being contained in alpha(1→4)-galacturonic-alpha(1→2)-rhamnose residues, wherein the molar ratio of galacturonic acid residues to rhamnose residues in the RG-I polysaccharides is within the range of 20:1 to 1:1;
- said method comprising oral administration of 0.1-5 grams of RG-I polysaccharides per day to the subject during a period of at least 3 days,
- wherein the stabilizing of healthy microbiota is by
- reducing intra-individual variability of the gut microbiota in a subject over time;
- and/or
- reducing inter-individual variability of the gut microbiota within a group of subjects.
Dependencies are inferred from the claim text.