Oral Brexanolone Compositions and Methods of Preparation and Use

A method for use in treating depression comprising administering a treatment regimen to a subject having depression,

• wherein said regimen comprises administering a dose of at least one of at least one solid dosage form, at least two solid dosage forms, at least three solid dosage forms, and at least four solid dosage forms, and
• wherein said at least one solid dosage form comprises brexanolone, and
• wherein said at least one solid dosage form comprises at least one solid dosage form of at least about 10 mg, at least about 15 mg, at least about 20 mg, at least about 25 mg, at least about 30 mg, at least about 35 mg, at least about 40 mg, at least about 45 mg, at least about 50 mg, at least about 55 mg, at least about 60 mg, at least about 65 mg, at least about 70 mg, at least about 75 mg, at least about 80 mg, at least about 85 mg, at least about 90 mg, at least about 95 mg, at least about 100 mg, at least about 110 mg, at least about 120 mg, at least about 130 mg, at least about 140 mg, at least about 150 mg, at least about 160 mg, at least about 170 mg, at least about 180 mg, at least about 190 mg, at least about 200 mg, at least about 225 mg, at least about 250 mg, at least about 300 mg, at least about 350 mg, at least about 400 mg, at least about 450 mg, at least about 500 mg, at least about 550 mg, at least about 600 mg, at least about 700 mg, at least about 800 mg, at least about 900 mg, at least about 1000 mg, at least about 1100 mg, and at least about 1200 mg, and
• wherein said regimen comprises a dosing interval frequency of at least one of about one hour, about two hours, about three hours, about four hours, about six hours, about eight hours, about twelve hours, and about 24 hours, and
• wherein said regimen comprises a minimum duration of at least one of 1 day, 2 days, 2.5 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, 10 days, 12 days, 14 days, 16 days, 18 days, 20 days, 21 days, 22 days, 24 days, 26 days, 28 days, 30 days, and more than 30 days.