Phenyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid derivates for use as 5-alpha reductase antagonists in methods of treatment
AssigneeUniversity of Cape Town
InventorsAfolake Arowolo, Nonhlanhla Patience Khumalo, Ogheneochuko Utieyin Oputu, Sincengile Nokubonga Ntshingila, Stephen Fienberg
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Abstract
The present invention provides for compounds that are phenyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid derivates for use as 5-alpha reductase antagonists, in particular as type 1 and type 2 antagonists. The invention further provides for pharmaceutical compositions comprising these compounds, and the use of these compounds and compositions in the treatment of diseases or disorders, in particular but not exclusively, in the treatment of benign prostatic hyperplasia and androgenetic alopecia.
Claims27
A pharmaceutical composition comprising a compound of the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate thereof, and a pharmaceutically acceptable carrier,
- wherein,
- R1, R1′, R2, R2′, and R3 are each independently selected from the group consisting of H, halogen, and —OR5,
- R5 is selected from substituted or unsubstituted C1-C2alkyl, substituted or unsubstituted, linear or branched C3-C6alkyl, and
- R4 is selected from substituted or unsubstituted C1-C2alkyl, substituted or unsubstituted, linear or branched C3-C6alkyl, and substituted or unsubstituted C3-C6cycloalkyl.
(canceled)
A method of treating a disease or a disorder in a patient, the method comprising administering to the patient, a compound of the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate thereof, or a pharmaceutical composition comprising the compound of the Formula (I), or a pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate thereof,
- wherein,
- R1, R1′, R2, R2′, and R3 are each independently selected from the group consisting of H, halogen, and —OR5,
- R5 is selected from substituted or unsubstituted C1-C2alkyl, substituted or unsubstituted, linear or branched C3-C6alkyl, and
- R4 is selected from substituted or unsubstituted C1-C2alkyl, substituted or unsubstituted, linear or branched C3-C6alkyl, and substituted or unsubstituted C3-C6cycloalkyl.
(canceled)
Dependencies are inferred from the claim text.