Ketone body and ketone body ester for reducing muscle breakdown
AssigneeTdeltas Limited
InventorsKieran Clarke, Peter Cox
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Abstract
Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-β-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
Claims21
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The method of claim 20 comprising a D-β-hydroxybutyrate ester of polyhydric alcohol wherein the polyhydric alcohol is not fully esterified.
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The method of claim 20 wherein the loss of leucine, isoleucine and valine in the subject is reduced by at least 10% after administration of the D-β-hydroxybutyrate compound as compared to the loss of leucine, isoleucine and valine in the subject without administration of the D-β-hydroxybutyrate compound.
The method of claim 20 wherein the loss of glycogen in the subject is reduced by at least 10% after administration of the D-β-hydroxybutyrate compoundketone as compared to the loss of glycogen in the subject without administration of the D-β-hydroxybutyrate compound.
The method of claim 20 wherein the rate of loss of glycogen or protein is reduced during exercise after administration of the D-β-hydroxybutyrate compound compared to the level of glycogen without administration of the D-β-hydroxybutyrate compound.
The method of claim 20 comprising the D-β-hydroxybutyrate ester of a polyhydric alcohol wherein the polyhydric alcohol is not fully esterified wherein the circulating levels of hydroxybutyrate and acetoacetate in the blood of the subject are from 1 to 10 mM.
A method of reducing glycogen and/or protein breakdown in a healthy subject comprising administering to the subject a D-β-hydroxybutyrate compound selected from:
- i) a D-β-hydroxybutyrate ester of a polyhydric alcohol wherein the polyhydric alcohol is not fully esterified;
- ii) an oligomer of D-β-hydroxybutyrate;
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- iii) a precursor of D-β-hydroxybutyrate capable of being metabolized to D-β-hydroxybutyrate in the human body a D-β-hydroxybutyrate ester of a polyhydric alcohol wherein the polyhydric alcohol is not fully esterified.
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The method of claim 21, wherein the composition further comprises a mid-chain triglyceride.
A method of improving endurance during exercise comprising administering to a healthy subject, before or during exercise, a D-β-hydroxybutyrate compound selected from:
- i) a D-β-hydroxybutyrate ester of a polyhydric alcohol wherein the polyhydric alcohol is not fully esterified;
- ii) an oligomer of D-β-hydroxybutyrate;
- and
- iii) a precursor of D-β-hydroxybutyrate capable of being metabolized to D-β-hydroxybutyrate in the human body.
A method of improving endurance during exercise comprising administering to a healthy subject, before or during exercise, a composition comprising water and a D-β-hydroxybutyrate compound selected from:
- i) a D-β-hydroxybutyrate ester of a polyhydric alcohol wherein the polyhydric alcohol is not fully esterified;
- ii) an oligomer of D-β-hydroxybutyrate;
- and
- iii) a precursor of D-β-hydroxybutyrate capable of being metabolized to D-β-hydroxybutyrate in the human body.
Dependencies are inferred from the claim text.