Lipid compounds and methods of making and use thereof

A compound defined by Formula I, or a pharmaceutically acceptable salt thereof:

• wherein
• X and Z are each independently O, NRa, or S;
• Ra, when present, is hydrogen or substituted or unsubstituted C1-C10 alkyl;
• R1, R2, and R3 are each independently H, OH, halogen, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkoxy;
• p is an integer from 0 to 5;
• q is an integer from 0 to 5;
• n is an integer from 1 to 10;
• m in each case is independently an integer from 1 to 10;
• y is an integer from 1 to 10;
• each R4, when present, is independently hydrogen or a substituted or unsubstituted C1-C18 alkyl;
• each R5, when present, is independently a substituted or unsubstituted C8-C18 alkyl;
• and
• R6 and R7 are each independently a substituted or unsubstituted C8-C18 alkyl.