Loading patent…
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsStephen Francis Badylak, George S. Hussey, Heth Turnquist, Jenna Lynn Dziki, Quan Liu, Zhongqiang Zhang
Estimating the term…
Methods are disclosed for treating a subject with a disorder, such as, but not limited to, a) fibrosis of an organ or tissue; b) solid organ transplant rejection; or c) a cardiac disease that is not myocardial infarction or myocardial ischemia. These methods include selecting a subject having or at risk of having the disorder, and administering to the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles contain interleukin (IL)-33 and comprise lysyl oxidase, and wherein the nanovesicles a) do not express CD63 or CD81, or b) are CD63loCD81lo. In additional embodiments, methods are disclosed for increasing myoblast differentiation.
1-32. (canceled)
A method of treating or inhibiting fibrosis of an organ or tissue in a subject in need thereof comprising administering to the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles comprise interleukin (IL)-33 and lysyl oxidase, and wherein the nanovesicles do not express CD63 or CD81, or b) are CD63loCD81lo, thereby treating or inhibiting fibrosis in the organ or tissue in the subject.
Dependencies are inferred from the claim text.