Perfluorinated micelles and medical uses thereof
AssigneesCommissariat A L'energie Atomique Et Aux Energies Alternatives, Universite Paris-Saclay, Centre National De La Recherche Scientifique, Inserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsEric DORIS, Edmond GRAVEL, Sophia GODEL, Charles TRUILLET, Erika PORCEL, Lucie JAMGOTCHIAN
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Abstract
A biocompatible micelle composition, for use as a medicament. The composition comprises micelles having a plurality of amphiphilic molecules. The amphiphilic molecules have a molecular weight of at least 500 Da and have at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic moiety. The micelles have an average hydrodynamic diameter of 40 nm or less.
Claims20
A biocompatible micelle composition, comprising:
- micelles having an average hydrodynamic diameter of 40 nm or less,
- wherein the micelles comprise amphiphilic molecules, the amphiphilic molecules comprise at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic moiety, and the amphiphilic molecules have a molecular weight of at least 500 Daltons.
2-3. (canceled)
An amphiphilic molecule, comprising at least one hydrophobic perfluorinated moiety linked to a hydrophilic metal complexing moiety, wherein the hydrophilic metal complexing moiety comprises desferrioxamine or a derivative thereof.
A biocompatible micelle composition, comprising micelles comprising:
- amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic moiety;
- and
- amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic metal complexing moiety comprising desferrioxamine or a derivative thereof.
A kit, comprising:
- amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic moiety;
- and
- amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic metal complexing moiety comprising desferrioxamine or a derivative thereof.
A method for preparing a micelle composition, comprising:
- a) bringing into contact (i) amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic moiety, and (ii) amphiphilic molecules comprising at least one hydrophobic perfluorinated moiety linked to at least one hydrophilic metal complexing moiety comprising desferrioxamine or a derivative thereof;
- and
- b) optionally ultra-sonicating the composition obtained at step a).
Dependencies are inferred from the claim text.