Bcma-specific antibody constructs and compositions thereof
AssigneeL'oreal
InventorsJeremy M. KINDER, Neal VAN HOEVEN
Life of this patent
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Abstract
Disclosed herein are antibodies or antigen binding fragments thereof that specifically bind human BCMA. Also disclosed are chimeric antigen receptors and chimeric antigen receptor transgenes comprising an antigen binding domain that specifically binds human BCMA. Also described herein are immune cells, viral vectors, and other compositions containing the antibodies, antibody binding fragments, chimeric antigen receptors and/or chimeric antigen receptor transgenes.
Claims20
A skin perfecting and tightening composition comprising:
- (a) about 1 to about 15 wt. % of pullulan;
- (b) optionally, up to about 12 wt. % of one or more hydrophilic non-acrylate film-forming polymers other than pullulan, preferably one or more polyurethanes, more preferably, polyurethane-99;
- (c) about 1 to about 10 wt. % of one or more mineral clays, preferably laponite;
- (d) about 1 to about 10 wt. % of one or more particulate fillers;
- and
- (e) optionally, one or more water-soluble organic solvents;
- and
- (f) about 60 to about 90 wt. % water;
- wherein all weight percentages are based on a total weight of the composition;
- and
- wherein the composition is optionally free or essentially free from acrylate and/or methacrylate polymers and copolymers (e.g., sodium polyacrylate, acrylates copolymer, acrylates/isobornyl acrylate copolymer, C1-C4 alkyl(methacrylate) polymers) regardless of what other monomer units appear in the polymer and copolymer (and crosspolymer).
The composition of any one of the above claims, wherein the one or more mineral clays are selected from montmorilonite, hectorite, saponite, bidelite, kaolinite, montmorillonites, saponites, laponites, hectorites (including disteardimonium hectorite), smectites, illites, vermiculite, mica, synthetic mica, or a combination thereof, preferably wherein at least one of the one or more mineral clays is laponite.
The composition of any one of the above claims, wherein the one or more particulate fillers are selected from carnauba wax, fluorphlogopite, titanium dioxide, tin oxide, sodium acrylates crosspolymer-2, cellulose, perlite, silica, perlite, silica silylate, talc, mica, titanated mica, alumina, aluminum silicate, silica which may or may not be coated, fumed silica, polyamide, methyl methacrylate crosspolymer, poly(methyl (meth)acrylate), polyethylene powder, polymethylsilsesquioxane powder, nylon-12, cellulose, nylon-12, polyvinylalcohol crosspolymer, or a mixture thereof.
The composition of any one of the above claims, wherein the composition further comprises the one or more water-soluble organic solvents.
The composition of any one of the above claims, further comprising:
- (g) one or more fibers.
The composition of any one of the above claims, further comprising:
- (h) one or more skin active agents.
The composition of any one of the above claims, further comprising:
- (i) one or more miscellaneous ingredients selected from preservatives, fragrances, pH adjusters, salts, buffers, flavonoids, vitamins, botanical extracts, UV filtering agents, proteins, protein hydrolysates and/or isolates, hydrotropes, pearlescent agents, fillers, colorants, mattifying agents, or a combination thereof.
The composition of any one of the above claims, wherein the composition is an emulsion, suspension, or dispersion.
The composition of any one of the above claims, wherein at least one of the one or more hydrophilic non-acrylate film-forming polymers is polyurethane-99.
The composition of any one of the above claims being free or essentially free from acrylate and methacrylate polymers and copolymers.
A skin perfecting and tightening composition comprising:
- (a) about 1 to about 15 wt. % of pullulan;
- (b) optionally, up to about 12 wt. % of one or more hydrophilic non-acrylate film-forming polymers, preferably one or more polyurethanes, more preferably, polyurethane-99;
- (c) about 1 to about 10 wt. % of one or more mineral clays, preferably laponite;
- (d) about 1 to about 10 wt. % of one or more particulate fillers;
- (e) optionally, up to about 15 wt. % of one or more water-soluble organic solvents;
- (f) about 60 to about 90 wt. % water;
- (g) optionally, up to about 10 wt. % of one or more fibers;
- (h) optionally, one or more skin active agents;
- and
- (i) optionally, up to about 5 wt. % of one or more miscellaneous ingredients;
- wherein all weight percentages are based on a total weight of the composition;
- and
- wherein the composition is optionally free or essentially free from acrylate and/or methacrylate polymers and copolymers (e.g., sodium polyacrylate, acrylates copolymer, acrylates/isobornyl acrylate copolymer, C1-C4 alkyl(methacrylate) polymers) regardless of what other monomer units appear in the polymer and copolymer (and crosspolymer).
Dependencies are inferred from the claim text.