Guided renal denervation using nerve stimulation with blood pressure and renal blood velocity measurements, and associated systems, device, and methods

A system, comprising:

• an intravascular guidewire configured to be positioned inside a renal artery of a patient, wherein the intravascular guidewire comprises a flow sensor;
• and
• a processor circuit configured for communication with the flow sensor,
• wherein the processor circuit is configured to:
• determine if renal denervation is recommended for a patient based on a comparison between blood flow velocity with and without renal nerve stimulation affecting the blood flow velocity differently than intravascular pressure, wherein a renal nerve is proximate to the renal artery;
• and
• provide, to a display in communication with the processor circuit, an output based on if the renal denervation is recommended for the patient,
• wherein, to determine if the renal denervation is recommended for the patient, the processor circuit is configured to:
• receive, from the flow sensor, a first intravascular measurement of the blood flow velocity without the renal nerve stimulation;
• receive, from the flow sensor, a second intravascular measurement of the blood flow velocity with the renal nerve stimulation;
• and
• perform the comparison between the first and second intravascular measurements of the blood flow velocity,
• wherein the first and second intravascular measurements of the blood flow velocity are obtained from inside the renal artery and obtained before the renal denervation.