Intestinal catheter device and system

A method of treating mucosal tissue in a duodenum of a patient, the method comprising:

• introducing into the duodenum of the patient a catheter comprising an elongate shaft and an expandable functional assembly disposed on a distal portion of the elongate shaft, the expandable functional assembly comprising:
• (i) at least one expandable reservoir configured to receive a heated liquid for hydrothermal ablation of mucosal tissue,
• (ii) a plurality of tissue capture chambers disposed on the expandable functional assembly, and
• (iii) a plurality of injectate delivery elements respectively associated with the plurality of tissue capture chambers;
• positioning the expandable functional assembly at a first target location in the duodenum distal to an ampulla of Vater;
• applying vacuum to the plurality of tissue capture chambers and delivering injectate through the plurality of injectate delivery elements to expand submucosal tissue at the first target location;
• under direct endoscopic visualization, determining whether the expanded submucosal tissue at the first target location is adequate for ablation;
• and
• responsive to determining that the expanded submucosal tissue is adequate, delivering the heated liquid to the at least one expandable reservoir to hydrothermally ablate mucosal tissue at the first target location with the expandable functional assembly, wherein the hydrothermal ablation is performed without repositioning the expandable functional assembly after the expanding of the submucosal tissue.

An ablation catheter for treating mucosal tissue in a duodenum of a patient, the ablation catheter comprising:

• an elongate shaft having a distal portion;
• an expandable functional assembly disposed on the distal portion and comprising at least one expandable reservoir configured to receive a heated liquid for hydrothermal ablation of mucosal tissue;
• at least two tissue capture chambers disposed on the expandable functional assembly, each tissue capture chamber being configured to capture tissue upon application of vacuum;
• at least two injectate delivery elements respectively associated with the at least two tissue capture chambers and configured to deliver injectate into tissue captured by the at least two tissue capture chambers;
• at least two vacuum delivery conduits respectively fluidly connected to the at least two tissue capture chambers;
• at least two injectate delivery conduits respectively fluidly connected to the at least two injectate delivery elements;
• a first fluid conduit fluidly connected to the at least one expandable reservoir and configured to deliver fluid to the at least one expandable reservoir;
• and
• a second fluid conduit fluidly connected to the at least one expandable reservoir and configured to remove fluid from the at least one expandable reservoir,
• wherein the at least two tissue capture chambers, the at least two injectate delivery elements, and the at least one expandable reservoir are co-located on the expandable functional assembly such that the ablation catheter is configured to expand submucosal tissue and thereafter hydrothermally ablate mucosal tissue at a same axial location without repositioning the expandable functional assembly.