Methods and systems for cryopreservation of biosystems using a cryomesh

Abstract

Methods for cryopreservation of biological samples are provided. The biological samples are sub-millimeter or millimeter scale biological materials. The cryopreservation system includes the use of a conduction-dominated cryomesh (CondD-C). The methods include loading the CondD-C with biological samples and submerging the CondD-C with the samples in a manner, e.g., by vertical plunging, that removes the vapor bubbles from the cooling surfaces. Methods using the CondD-C and vertical plunging can enhance the cooling rate and warming rates and are scalable for high throughput processing of large numbers of vitrified and/or rewarmed biological samples.

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