Microfluidic devices for enhanced micromixing and detection sampling
AssigneeBattelle Savannah River Alliance, LLC
InventorsCHRISTOPHER A. SOBECKI, STEVEN M. DEMERS, INGRID LEHMAN-ANDINO
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Abstract
A device, system, and method incorporating a microfluidic device for enhanced mixing and detection sampling is disclosed. The microfluidic device may include one or more sensors and an analyte solution. The one or more sensors and the analyte solution may be contacted in the microfluidic device and may be used to determine whether the analyte solution contains one or more chemical, biological, and/or radiological/nuclear (CBRN) threats.
Claims21
A system for detecting chemical, biological and/or radiological/nuclear (CBRN) threats, the system comprising:
- a microfluidic device, the microfluidic device comprising one or more inlet channels and one or more outlet channels, the microfluidic device comprising paper;
- a reservoir, the reservoir being in fluid communication with the microfluidic device;
- and
- a sensor for the detection of one or more chemical, biological and/or radiological/nuclear (CBRN) threats, the sensor comprising:
- a nanoparticle;
- and
- a first energy transfer pair comprising a first donor, a first acceptor, and a first linking agent linking the first donor and the first acceptor, the linking agent comprising a first polynucleic acid, the first polynucleic acid comprising a first specific binding ligand for a first CBRN threat, wherein the nanoparticle is the first donor or the first acceptor.
A system for detecting chemical, biological and/or radiological/nuclear (CBRN) threats, the system comprising:
- a microfluidic device, the microfluidic device comprising paper, the microfluidic device comprising two or more inlet channels and one or more outlet channels, the two or more inlet channels comprising an analyte solution and a sensor for the detection of one or more chemical, biological and/or radiological/nuclear (CBRN) threats;
- and
- a reservoir, the reservoir being in fluid communication with the microfluidic device.
A system for detecting chemical, biological and/or radiological/nuclear (CBRN) threats, the system comprising:
- a mobile analysis device, the mobile analysis device comprising:
- a microfluidic device, the microfluidic device comprising paper, the microfluidic device comprising a sensor for the detection of one or more chemical, biological and/or radiological/nuclear (CBRN) threats;
- and
- a reservoir, the reservoir being in fluid communication with the microfluidic device.
A method for detecting chemical, biological and/or radiological/nuclear (CBRN) threats, the method comprising:
- contacting a sensor with an analyte solution in a microfluidic device, the microfluidic device comprising paper, the sensor comprising a nanoparticle;
- a first energy transfer pair comprising a first donor, a first acceptor, and a first linking agent linking the first donor and the first acceptor, the first linking agent comprising a first polynucleic acid that includes a first specific binding ligand for a first CBRN threat;
- and
- examining the sensor for an optically detectable signal after contact of the sensor and the analyte solution.
Dependencies are inferred from the claim text.