US 2026/0193685 A1 · NUCLEIC ACID MODIFIED TO OBTAIN ENHANCED ERGOTHIONEINE PRODUCTIVITY, AND MICROORGANISM HAVING GENETIC MODIFICATION

Abstract

The purpose of the present invention is to enhance ergothioneine productivity in ergothioneine production through culturing of an ergothioneine-producing filamentous fungus. In the present invention, a genetic mutation that enhances ergothioneine production in an ergothioneine-producing filamentous fungus is identified. The present invention provides: a nucleic acid that includes a conserved region at positions 433-440 in SEQ ID NO. 1 and that has, in a sequence corresponding to SEQ ID NO. 1, a deletion of a region included in a functional domain corresponding to a functional domain at W404-Q515 in SEQ ID NO. 1; and a filamentous fungus having said nucleic acid.

Claims20

Dependent claims

Nucleic acid coding for:

a sequence corresponding to the sequence of SEQ ID NO:
1, comprising a conserved region within SEQ ID NO:
1, wherein the sequence has a mutation in a region within a functional domain corresponding to the functional domain of W404 to 0515 of SEQ ID NO:
1, whereby the function of the functional domain is modulated;
or
a sequence having at least 90% identity with said sequence,
wherein the nucleic acid enhances ergothioneine production when introduced into an ergothioneine-producing microorganism.

4 more elements

Dependencies are inferred from the claim text.

Nucleic acid modified to obtain enhanced ergothioneine productivity, and microorganism having genetic modification

Life of this patent

Nucleic acid modified to obtain enhanced ergothioneine productivity, and microorganism having genetic modification

Life of this patent

Abstract

Claims20