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US 2026/0193608 A1Published application
Method for the production of gamma delta t cells for immunotherapy applications
AssigneeJi Yan Biomedical Co., Ltd.
InventorsBo-Xiang ZHANG, Hsieh-Tsung SHEN
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Abstract
The present disclosure relates to a field of immunotherapy. Particularly, the present disclosure provides methods for production of gamma delta T (γδ T) cells and the γδ T cells produced therefrom.
Claims20
A method for producing a γδ T cell population comprising enriched Vδ2+ γδ T cells, comprising:
- (a) providing peripheral blood mononuclear cells (PBMCs);
- optionally the Vδ2+ γδ T cells contained in the PBMCs are separated by immunomagnetic separation to obtain a Vδ2+ γδ T cell subpopulation;
- (b) culturing the PBMCs or Vδ2+ γδ T cell subpopulation in a medium containing zoledronic acid and one or more growth factors having interleukin-like activity to specifically enrich Vδ2+ γδ T cells to obtain an enriched Vδ2+ γδ T cell population;
- and
- (c) harvesting the expanded Vδ2+ γδ T cell population.
2 more elements
Dependencies are inferred from the claim text.