Preparation of medium molecular weight heparin
AssigneeGlycos Biomedical Ltd
InventorsPervinder Singh BHOGAL, John BRACKETT, Graham RUSHTON
Life of this patent
Estimating the term…
Abstract
A method of synthesis of medium molecular weight heparin includes the steps of dissolving unfractionated heparin in an aqueous buffer solution adjusted to between about pH 5.0 and about pH 9.0 to provide a first solution; adding an oxidising agent to the first solution to provide a second solution; and incubating the second solution at a temperature of from about 0° C. to about 10° C. to form a medium molecular weight heparin solution.
Claims26
A method of synthesis of medium molecular weight heparin, the method comprising the steps of:
- a. dissolving unfractionated heparin in an aqueous buffer solution adjusted to between about pH 5.0 and about pH 9.0 to provide a first solution;
- b. adding an oxidising agent to the first solution to provide a second solution;
- and
- C. incubating the second solution at a temperature of from about 0° C. to about 10° C. to form a medium molecular weight heparin solution.
A kit suitable for preparing medium molecular weight heparin, wherein the kit comprises:
- a. unfractionated heparin;
- b. an aqueous buffer solution adjusted to between about pH 5.0 and about pH 9.0;
- c. an oxidising agent;
- and
- d. optionally, an inactivating agent.
-75. (canceled)
Dependencies are inferred from the claim text.