Anti-alpha5 integrin antibodies and uses thereof
AssigneePasithea Therapeutics Corp.
InventorsLisa RYNER, Michael LEVITEN
Life of this patent
Estimating the term…
Abstract
The present disclosure provides antibodies or antigen-binding fragments thereof that bind to α5 integrin (e.g., human α5 integrin) and uses thereof. In certain embodiments, the disclosed antibodies are humanized antibodies.
Claims74
An anti-α5 integrin antibody or an antigen-binding fragment thereof comprising a heavy chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 31.
An anti-α5 integrin antibody or an antigen-binding fragment thereof comprising a heavy chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 32.
An anti-α5 integrin antibody or an antigen-binding fragment thereof comprising a light chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 33.
An anti-α5 integrin antibody or an antigen-binding fragment thereof comprising a light chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 34.
An anti-α5 integrin antibody or an antigen-binding fragment thereof comprising:
- (a) a heavy chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 31 or SEQ ID NO:
- 32;
- and
- (b) a light chain variable region that comprises an amino acid sequence that is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth in SEQ ID NO:
- 33 or SEQ ID NO:
- 34.
Dependencies are inferred from the claim text.