Biomarker for predicting risk of drug addiction relapse and animal model with high relapse of drug addiction
AssigneeKorea Institute of Science and Technology
InventorsHeh-In IM, Jin Hee BAE, Eun Mi HWANG
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Abstract
The present disclosure has, for the first time, identified the relationship between the expression level of MeCP2 in D2R neurons of a ventral striatum and relapse of drug addiction, and provides this as a biomarker for predicting relapse of drug addiction. Furthermore, an animal model in which MeCP2 expression is suppressed specifically in D2R neurons of the ventral striatum has been developed, which is expected to greatly contribute to elucidating the mechanism of relapse of drug addiction and developing therapeutics therefor.
Claims12
A pharmaceutical composition for preventing relapse of drug addiction, comprising as an active ingredient an agent capable of increasing an expression level of MeCP2 specifically in D2R neurons of a ventral striatum,
- wherein the agent is a vector comprising an MeCP2 gene.
A method of producing an animal model with high relapse of drug addiction, the method comprising knocking down an MeCP2 gene specifically in D2R neurons in a ventral striatum of a non-human subject.
An animal model with high relapse of drug addiction in which expression of MeCP2 is suppressed specifically in D2R neurons in a ventral striatum.
Dependencies are inferred from the claim text.