Gene constructs encoding fusion proteins having binding capacity for strep-tag binding substances, and expression vectors, recombinant strains and anticancer compositions comprising the same

Abstract

A gene construct encoding a fusion protein having specific binding capacity for strep-tag binding substances. The C-terminus of the curli-related CsgA gene of Gram-negative bacteria is linked to a strep-tag gene. The strep-tag binding substances include biotin, avidin, streptavidin, and strep-tactin. The CsgA gene and the strep-tag gene are linked directly or via a linker. A plurality of strep-tag genes are linked in tandem or through a linker.

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