Class of polypeptides targeting protein degradation and application thereof

Abstract

Compositions and methods of generating polypeptides targeting protein degradation are described. The polypeptide is any one of the following a1) to a4): a1) a polypeptide having an amino acid sequence comprising an amino acid sequence shown in positions 15 to 24 of SEQ ID No: 3; a2) a fused polypeptide obtained by attaching a protein-tag to an N-terminus and/or a C-terminus of the polypeptide of a1); a3) a polypeptide having a same function obtained by substitution and/or deletion and/or addition of one or several amino acid residues of the amino acid sequence of a1); a4) a polypeptide having 80% or more identity and having the same function with the amino acid sequence of a1). Experimentally, the polypeptides reduced the number of pathogens, promoted the lysis of pathogens, and killed the pathogens in citrus infected with Huanglongbing, also known as citrus greening.

Dependencies are inferred from the claim text.