Gramine-platinum (iv) complex as well as preparation method therefor and anti-tumor use thereof

Abstract

The present disclosure relates to a gramine-platinum (IV) complex as well as a preparation method therefor and the anti-tumor use thereof. One gramine molecule is introduced to one side of the axial direction of a platinum (IV) coordination center to form a mono-substituted tetravalent platinum complex; or one gramine molecule is introduced to one side of the axial direction of the platinum (IV) coordination center, and one molecule of a —NH-aliphatic chain group or an aliphatic chain group is introduced to the other side so as to form a bi-substituted tetravalent platinum complex. The prepared complex has stronger killing ability on tumor cells, and has obviously improved anti-proliferative activity in various cell lines; and in triple-negative breast cancer cells having an extremely high malignant degree, the complex compared with clinical platinum drugs has most remarkable effect improvement. The gramine-platinum (IV) complex of the present disclosure has a simple synthesis process and low cost; said complex greatly improves the curative effect of combined drug therapy; and compared with traditional divalent platinum and similar tetravalent platinum drugs, said complex has the advantages of good curative effect, small side effect and the like.

Dependencies are inferred from the claim text.