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US 2026/0193229 A1Published application
Brisc deubiquitinating enzyme inhibitors
OwnerRoger GREENBERG, Frank SICHERI +2inventors
InventorsRoger GREENBERG, Frank SICHERI, Elton ZEQIRAJ, Joseph M. SALVINO
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Abstract
The present disclosure provides for techniques using BRISC deubiquitinating enzyme inhibitors of formula (I) for treating and/or preventing systemic lupus erythematosus (SLE). Accordingly, the present disclosure provides for compositions and methods for treating or preventing a disease or disorder mediated by inhibition of type I interferon receptor (IFNAR1) signaling.
Claims20
A compound of Formula I:
- or a salt, ester, or solvate thereof,
- wherein R1 is C═O, SO2-Me, carbonyl, or a sulfonyl;
- wherein R2 is optional, and if present, is CF3, C1-6alkyl, substituted C1-6alkyl, amino, alkoxycarbonyl, aryl, substituted aryl, benzyl, or a substituted naphthalene;
- wherein R3 is a substituted amino;
- and
- wherein R4 is H or an amino.
3 more elements
Dependencies are inferred from the claim text.