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US 2026/0193219 A1Published application
Triazine derivatives for treating diseases relating to neurotrophins
AssigneeAlzeCure Pharma AB
InventorsGunnar Nordvall, Pontus Forsell
Life of this patent
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Abstract
There is provided a compound of formula I, wherein R1 and R2 are as defined herein, which compounds are useful in the treatment of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease and the like.
Claims26
1-26. (canceled)
A compound of formula I,
- wherein:
- R1 represents
- wherein
- represents the point of attachment to the nitrogen atom;
- R3 represents hydrogen, methyl or methoxymethyl;
- R4 represents hydrogen, methoxy or methoxymethyl;
- R2 represents methyl, ethyl, methoxymethyl, methylsulfanyl or -A-R5;
- wherein
- A represents C1-2 alkylene, —C1-2alkyleneO-, or —OC1-2alkylene-, which three groups are optionally substituted by one or more groups selected from halo, C1-2 alkyl and ═0;
- and
- R5 represents oxetanyl or a 4-7-membered nitrogen-containing heterocyclyl group, each of which groups are optionally substituted by one or more groups selected from halo, C1-2 alkyl and ═O;
- or a pharmaceutically-acceptable salt thereof, with the proviso that the compound of formula I does not represent
9 more elements
Dependencies are inferred from the claim text.