A process for the synthesis of stilbene and intermediates thereof
AssigneeFertis India Pvt Ltd
InventorsRahul Raju KANUMURU, Shaji George KOCHUMALAYIL, Ravikumar SURANENI, Murali Mohanarao VANA
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Abstract
The present invention discloses a process for the preparation of Stilbene such as Pterostilbene and Resveratrol. More particularly, the present invention discloses synthesis of Stilbene employing a novel intermediate, 5-(4-(1-ethoxyethoxy) styryl)-benzene 1,3 diol and 1-(4-(1-ethoxyethoxy) styryl)-3,5-dimethoxy-benzene.
Claims10
A process for the preparation of Stilbene comprising;
- (iii) condensing 4-(1-ethoxyethoxy)benzaldehyde with a compound of formula 3 in presence of a base;
- wherein, R1 and R2 are individually selected from the group consisting of hydrogen, methyl, alkyl, aryl and arylalkyl,
- to obtain compound of formula 4;
- and
- wherein, R1 and R2 are individually selected from the group consisting of hydrogen, methyl, alkyl, aryl and arylalkyl,
- (iv) deprotecting the compound of formula 4 to yield Stilbene of formula 5
A compound of formula 4,
- wherein R1 and R2 are hydrogen or methyl.
A process for the synthesis of compound of formula 4, which process comprises a step of condensing benzyl phosphonate compound of 3 with 4′-O-ethylvinyl ether benzaldehyde (2) in the presence of a base,
- wherein R1 and R2 independently represent hydrogen or methyl.
Dependencies are inferred from the claim text.