Closure Integrity-Preserving Kit, Fixation Clip, and Plunger Rod for a Prefilled Syringe

A kit for preserving sterility of a prefillable syringe, the kit comprising:

• a syringe barrel,
• a plunger rod for attachment with a stopper for use with the syringe barrel, the plunger rod comprises an elongated body having a distal attachment end configured for attachment to the stopper and a proximal end, and the elongated body extending along a longitudinal axis between the distal end and the proximal end, the plunger rod further comprising one or more ridges extending sideways from the elongated body and spaced apart along thereof, and
• a fixation clip comprising one or more notches matching in size and spacing to the one or more ridges of the plunger rod, wherein the fixation clip is configured to removably attach to the plunger rod such that one or more ridges of the plunger rod are positioned within one or more notches of the fixation clip,
• whereby upon inserting the plunger rod and the stopper into the syringe barrel and filling the syringe with a medical liquid, placement of the fixation clip onto the plunger rod adjacent the syringe barrel causes the fixation clip to extend outwardly from the plunger rod beyond the syringe barrel, which in turn prevents the plunger rod and the stopper from unintended longitudinal movement along the syringe barrel, and
• wherein
• the fixation clip comprises a pair of hingedly-connected V-shaped arms forming a normally-closed clamp, each arm defining a first end and a second end, wherein the one or more notches are positioned at the first end of at least one of the arms, and wherein the first ends of the arms include a sloped leading edge that engages the plunger rod as the fixation clip is brought toward the plunger rod in a direction transverse to the longitudinal axis of the plunger rod, with a force of contact between the plunger rod and the sloped leading edges causing the first ends of the arms to separate, allowing the fixation clip to fully seat on the plunger rod.