Gdnf mimetic peptide amphiphiles
AssigneeNorthwestern University
InventorsSamuel Isaac Stupp, Oscar Alejandro Carballo Molina
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Abstract
Provided herein are peptide amphiphiles (PAs) and supramolecular PA nanostructures that mimic glial derived neurotrophic factor (GDNF), a growth factor that induces neuronal survival, maturation, and increased electrical activity. In particular, injectable biomaterials comprising GDNF mimetic PAs are provided, as well as methods of using GDNF mimetic PAs for the treatment or prevention of neurological injuries, diseases, and disorders, including concurrently with cell replacement therapy.
Claims20
A GDNF mimetic peptide amphiphile comprising a hydrophobic tail, a structural peptide segment, a charged peptide segment, and a glial derived neurotrophic factor (GDNF) mimetic peptide.
Dependencies are inferred from the claim text.