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US 2026/0192015 A1Published application
Hydrogen sulfide-releasing grafts
OwnerXiaochu Dinginventor
Life of this patent
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Abstract
Exemplary hydrogen sulfide-releasing grafts may comprise backbones formed of first polymers and second polymers. Exemplary grafts may be biocompatible and degradable. Various methods may be used to generate exemplary grafts. Certain methods may involve electrospinning and, in some instances, the application of UV-light.
Claims20
An elastomeric graft comprising:
- a backbone comprising a first polymer crosslinked with a second polymer, the first polymer comprising:
- and
- where a ratio of X to (Y+Z) is between 20:80 and 55:45;
- where a ratio of Y to Z is between 10:90 and 25:75;
- where T is an integer from 0 to 6;
- where R is hydrogen or a polyester chain;
- where n is an integer from 2 to 50;
- and
- a second polymer comprising:
- where a ratio of M to P is between 40:60 and 60:40;
- and
- where G is an integer from 1 to 6.
9 more elements
A method for preparing an elastomeric graft, the method comprising:
- combining a compound of formula (I) with glycerol, sebacic acid, and a solvent in a first vessel, where formula (I) is:
- and
- where T is an integer from 0 to 6;
- and
- heating the first vessel to a temperature of 100° C. to 150° C.;
- while heating, purging the first vessel with nitrogen (N2) for a time period of 20 hours to 28 hours;
- after purging with nitrogen and while heating, applying a vacuum to the first vessel for a time period of 3 hours to 7 hours;
- thereby generating a compound of formula (II):
- and
- where a ratio of Y to Z is between 10:90 and 25:75;
- and
- where R is hydrogen or a polyester chain;
- combining the compound of formula (II) with poly(ε-caprolactone), sebacic acid, and a second solvent in a second vessel;
- heating the second vessel to a temperature of 100° C. to 150° C.;
- while heating, purging the second vessel with nitrogen for a time period of 20 hours to 28 hours;
- after purging with nitrogen and while heating, applying a vacuum to the second vessel for a time period of 7 hours to 40 hours;
- thereby generating a first polymer;
- combining a compound of formula (III), sebacic acid, a compound of formula (IV) and a third solvent in a third vessel, where formula (III) is:
- and
- where formula (IV) is:
- and
- where G is an integer from 1 to 6;
- heating the third vessel to a temperature of 100° C. to 150° C.;
- while heating, purging the third vessel with nitrogen for a time period of 20 hours to 28 hours;
- after purging with nitrogen and while heating, applying a vacuum to the third vessel for a time period of 70 hours to 80 hours;
- thereby generating a second polymer;
- combining the first polymer, the second polymer, a fourth solvent, and a radical initiator to form a crosslinking mixture;
- and
- electrospinning the crosslinking mixture to generate graft fiber.
26 more elements
Dependencies are inferred from the claim text.