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US 2026/0192003 A1Published application
Chelating compounds and methods of uses thereof
AssigneeThe Regents of the University of California
InventorsJoshua Woods, Rebecca J. Abergel
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Abstract
The present invention provides for a metal chelator capable of binding a radioisotope or radionuclide, and bioconjugate thereof, and methods of making and using thereof.
Claims18
A metal chelator having a chemical structure comprising:
- or a bioconjugate thereof;
- wherein Ra, Rb, Rc, and Rd each independently comprises:
- (a) a HOPO group having the following chemical structure:
- wherein α is a
- —CHOH—(CH2)n—, or —(CH2)n—;
- each Rx is independently a H, —OH or alkyl group;
- and n is an integer from 0 to 10;
- (b) a HA group having the following chemical structure:
- wherein Rα is a —H or alkyl group;
- or,
- (c) a CAM group having the following chemical structure:
8 more elements
A method for treating a subject in need of such treatment, the method comprising:
- administering a therapeutically effective amount of a pharmaceutical composition comprising a bioconjugated metal chelator comprising a metal chelator bound to a radioisotope or radionuclide and a biological targeting vector (BTV), wherein the metal chelator has a chemical structure comprising:
- wherein Ra, Rb, Rc, and Rd each independently comprises:
- (a) a HOPO group having the following chemical structure:
- wherein α is a
- —CHOH—(CH2)n—, or —(CH2)n—;
- each Rx is independently a H, —OH or alkyl group;
- and n is an integer from 0 to 10;
- (b) a HA group having the following chemical structure:
- wherein Rα is a —H or alkyl group;
- or,
- (c) a CAM group having the following chemical structure:
- to the subject;
- wherein the BTV of the bioconjugated metal chelator targets a cancer cell in the subject.
10 more elements
Dependencies are inferred from the claim text.