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US 2026/0191997 A1Published application
Conjugates having antifouling nanoparticles and methods of use
AssigneeBoard of Regents, The University of Texas System
InventorsJie ZHENG, Mengxiao YU
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Abstract
The present disclosure provides conjugates that comprise a small molecule attached to an antifouling nanoparticle. The present disclosure also provides methods of using such conjugates, such as diagnosis, tissue imaging, temporal monitoring, and treatment.
Claims75
A conjugate, comprising:
- a small molecule that binds an influx or efflux transporter;
- and
- an antifouling nanoparticle, wherein
- the small molecule is attached to the antifouling nanoparticle through a covalent bond or a metal-ligand bond, and
- when the small molecule is indocyanine green (ICG), the antifouling nanoparticle is not polyethylene glycol (PEG), and vice versa.
2 more elements
A conjugate comprising indocyanine green (ICG), polyethylene glycol (PEG), and a secondary moiety, wherein ICG and the secondary moiety are each independently conjugated to PEG.
Dependencies are inferred from the claim text.