Multi-arm polyethylene glycol-drug conjugate

Abstract

Disclosed in the present invention are a multi-arm polyethylene glycol-drug conjugate, and a preparation method therefor and the use thereof. In the multi-arm polyethylene glycol-drug conjugate provided in the present invention, the terminal position of the multi-arm polyethylene glycol structure thereof may be a heterofunctional group, so that two or even three drugs can be simultaneously connected in one molecular system, thereby achieving the aim of treating multiple diseases with one drug. In addition, compared with a linear multi-arm polyethylene glycol-drug conjugate, the multi-arm PEG has a plurality of terminal groups, has a plurality of introduction points of functional groups, and can be connected to a plurality of different active groups, thereby avoiding the problems of limited connection sites of linear PEG, a small application range, and low drug loading. Moreover, the multi-arm polyethylene glycol-drug conjugate can also be used in the field of antibody-drug conjugates. Compared with a linear linker, a heterofunctional multi-arm polyethylene glycol linker can greatly increase the drug loading of a single antibody-drug conjugate molecule.

Dependencies are inferred from the claim text.