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US 2026/0191958 A1Published application
Anti-mesothelin nanobody chimeric antigen receptor and use thereof
AssigneeShanghai Cell Therapy Group Co., Ltd.
InventorsXingli ZHU, Xiangzhen LIU, Yan SUN, Na DING, Qijun QIAN
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Abstract
Provided is a chimeric antigen receptor. An antigen binding domain thereof comprises a mesothelin binding molecule containing an anti-mesothelin single-domain antibody. Immune cells containing the chimeric antigen receptor described herein have a higher cell killing effect.
Claims22
A chimeric antigen receptor whose antigen-binding domain comprises a mesothelin-binding molecule containing an anti-mesothelin single domain antibody,
- the anti-mesothelin single domain antibody comprises CDR1, CDR2 and CDR3, wherein CDR1 comprises the sequence shown in any of SEQ ID NOs:
- 4-27 and 73, and/or CDR2 comprises the sequence shown in any of SEQ ID NOs:
- 28-47 and 74, and/or CDR3 comprises the sequence shown in any of SEQ ID NOs:
- 48-72 and 75.
1 more element
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Dependencies are inferred from the claim text.