Vp4-based trivalent pseudovirus nanoparticle vaccine for rotavirus and methods of using same

Abstract

Disclosed herein are vaccine compositions, in particular, polyvalent icosahedral compositions for presentation of a rotavirus antigen. The disclosed compositions may contain an S particle made up of recombinant fusion proteins that further comprise a rotavirus antigen. The recombinant fusion proteins may include a norovirus (NoV) S domain protein, a linker protein domain operatively connected to the norovirus S domain protein, and a rotavirus antigen protein domain. The disclosed particles and compositions may be used as a vaccine composition for reducing the likelihood of becoming infected with rotavirus, diminishing the severity of a rotavirus infection, reducing the duration of time of a rotavirus infection, or otherwise improving an immune response following contact with rotavirus in an individual.

Dependencies are inferred from the claim text.