Acinetobacter vaccine and method of use thereof
AssigneeWashington University
InventorsScott HULTGREN, Morgan TIMM, Kevin TAMADONFAR, Ali ELLEBEDY, Jerome PINKNER, Mario FELDMAN, Karen DODSON
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Abstract
The present disclosure provides for a vaccine comprising an Acinetobacter adhesin protein or fragment thereof and a pharmaceutically acceptable carrier or adjuvant. The vaccine may be used for treating or preventing a urinary tract infection (UTI) in a subject in need thereof, particularly a catheter-associated UTI (CAUTI). In some embodiments, the Acinetobacter adhesin protein or fragment thereof is an isolated Acinetobacter chaperone-usher pathway (CUP) adhesin protein or immunogenic fragment thereof.
Claims20
A vaccine comprising:
- at least one isolated Acinetobacter chaperone-usher pathway (CUP) adhesin protein or immunogenic fragment thereof;
- and
- a pharmaceutically acceptable carrier or adjuvant.
A method of treating or preventing a urinary tract infection (UTI) in a subject in need thereof, the method comprising administering to the subject a vaccine comprising at least one isolated Acinetobacter chaperone-usher pathway (CUP) adhesin protein or immunogenic fragment thereof and a pharmaceutically acceptable carrier or adjuvant.
Dependencies are inferred from the claim text.