Tissue occluding agent comprising an ieikieikieiki peptide
Assignee3-D Matrix, Ltd.
InventorsKentaro Takamura, Satoshi Gojo, Satoru Kobayashi
Life of this patent
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Abstract
There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.
Claims17
1-15. (canceled)
An aqueous solution comprising a peptide, wherein the peptide consists of SEQ ID NO:
- 3.
A powder comprising a peptide, wherein the peptide consists of SEQ ID NO:
- 3.
24-29. (canceled)
A method of elevating an excision site in endoscopic demucosation, the method comprising a step of:
- administering to the excision site an aqueous solution comprising a peptide, wherein the peptide consists of SEQ ID NO:
- 1, SEQ ID NO:
- 2, or SEQ ID NO:
- 3.
A method of suppressing hemorrhage and body fluid leakage from an excision site, the method comprising steps of:
- excising a mucosal tissue section that has been elevated by infusion of a liquid into the mucosal tissue, the liquid being an aqueous solution of a peptide, wherein the peptide consists of SEQ ID NO:
- 1, SEQ ID NO:
- 2, or SEQ ID NO:
- 3.
An endoscopic demucosation, wherein the improvement comprises applying a hemostatic agent via transcatheter application, the agent comprising an aqueous solution of a peptide, wherein the peptide consists of SEQ ID NO:
- 1, SEQ ID NO:
- 2, or SEQ ID NO:
- 3.
(canceled)
Dependencies are inferred from the claim text.