Freeze-dried plasma (fdp) for well-balanced coagulation and fibrinolysis, method of preparation and use thereof

Abstract

A freeze-dried plasma (FDP) for well-balanced coagulation and fibrinolysis, a method of preparation and use thereof are provided, relating to the technical field of hemostatic preparations. The FDP for well-balanced coagulation and fibrinolysis is compounded with appropriate concentrations of coagulation factors, anticoagulant factors, fibrinolytic factors, fibrinolysis inhibiting factors, and von Willebrand factor according to different changes in a coagulation-fibrinolysis system after different types of tissue and organ injuries. The FDP for well-balanced coagulation and fibrinolysis is used for hemostatic resuscitation of general severe trauma, severe hepatic trauma, severe craniocerebral injury, and severe trauma with seawater immersion and other types of injuries, exhibiting a desirable hemostatic resuscitation effect. It does not cause thrombosis in uninjured parts, and may reduce the amplitude of lactate increase after the trauma.

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