Method of producing local nerve block by administering composition comprising cyclodextrin
AssigneeSaol International Development Ltd.
InventorsJohn DEVANE, David PENAKE, Leonard O’MAHONY, Sharon HAMM, Lopa BHATT
Life of this patent
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Abstract
Disclosed are methods of treating pain by administering cyclodextrin which is majority unoccupied with a guest compound. The cyclodextrin may also be occupied with an inert molecule or agent as a guest, such as proline. Attenuation of pain treatment due to cyclodextrin may be performed by administration of an inert molecule or agent as a guest, such as proline, either before, after or simultaneously with administration of cyclodextrin.
Claims135
A method of treating pain in a subject in need of treatment, comprising:
- injecting the patient with a composition comprising a majority unoccupied cyclodextrin locally to a sensory nerve of a pain site or source, the cyclodextrin being majority unoccupied with a guest compound.
A method of treating pain in a subject in need of treatment, comprising:
- injecting the patient with a composition comprising cyclodextrin as a host and an inert molecule or agent as a guest locally to a sensory nerve of a pain site or source,
- wherein the inert molecule or agent does not cause membrane cell lysis in a red blood cell (RBC) test.
A method of attenuating a cytolytic effect of cyclodextrin in a subject receiving cyclodextrin treatment, having previously received cyclodextrin treatment, or planned to receive cyclodextrin treatment, comprising
- administering an inert molecule or agent to the subject, the inert molecule or agent being capable of occupying the cyclodextrin.
A method of treating spasticity in a subject in need of treatment, comprising:
- injecting the patient with a composition comprising a majority unoccupied cyclodextrin locally to a motor nerve of a muscle spasticity site or source, the cyclodextrin being majority unoccupied with a guest compound.
Dependencies are inferred from the claim text.