Use of Morinda officinalis oligosaccharides and composition thereof in prevention or treatment of depression
AssigneeNanjing Haiguang Institute of Applied Chemistry Co. Ltd
InventorsYan Wang, Xinjie Zhu, Haibin Luo, Song Li
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Abstract
Use of Morinda officinalis oligosaccharides represented by the following structural formula and a composition comprising the same and an intestinal flora in the preparation of a medicine for the preventing or treating depression. By means of a Trp-5-HTP-5-HT pathway, Morinda officinalis oligosaccharides and the intestinal flora are combined for use so as to increase the content of 5-HTP in the blood and the content of 5-HTP and 5-HT in the brain, thereby improving the treatment on depression. wherein n=1, 2, 3, 4, 5, 6 or 7.
Claims20
A method of preventing and/or treating depression, comprising administrating Morinda officinalis oligosaccharides as shown in the structural formula or any combination thereof,
- n=1, 2, 3, 4, 5, 6 or 7.
A method, comprising administrating Morinda officinalis oligosaccharides as shown in the structural formula or any combination thereof,
- n=1, 2, 3, 4, 5, 6 or 7;
- wherein the method is to increase the level of 5-hydroxytryptophan and/or 5-hydroxytryptamine:
- upregulate the level of peripheral 5-hydroxytryptophan and downregulate the level of 5-hydroxytryptamine, and increase the level of central 5-hydroxytryptamine;
- or increase the level of TPH and coenzyme BH4 thereof and/or reduce the level of 5-HTPDC and coenzyme VB6 thereof in a subject.
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Dependencies are inferred from the claim text.