Pyridine-2-thiol 1-oxide derivatives and their use for treatment of mammalian infections caused by mycobacterium or fungi
OwnerMaria Rosalia PASCA, Giulia DEGIACOMI +2inventors
InventorsMaria Rosalia PASCA, Giulia DEGIACOMI, Olga RIABOVA, Vadim MAKAROV
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Abstract
The present invention relates to pyridine-2-thiol 1-oxide derivatives and their use as antimicrobial agents in infectious diseases of mammals (humans and animals) caused by fungi or bacteria, in particular belonging to the Mycobacteriaceae family, especially diseases caused by Mycobacterium abscessus or Mycobacterium tuberculosis.
Claims16
A compound of formula (I)
- wherein R is selected from the group consisting of COOR1, CONR22 or CF3,
- wherein R1 is a linear C1-C3 alkyl group and R2 is selected between H and C1-C3 alkyl group;
- wherein X is selected from the group consisting of Na, Li, K, or Ca;
- and crystalline forms thereof;
- for use in the treatment or prevention of infections caused by Mycobacteria and/or fungi in a subject in need of such treatment.
The compound for use according to claim, wherein X is Na.
A sodium 5-(alkoxyl carbonyl)pyridine-2-thiolate 1-oxide for use in a medical field.
A sodium 5-(ethoxycarbonyl)pyridine-2-thiolate 1-oxide for use in a medical field.
Dependencies are inferred from the claim text.