Stabilizing vitamin c topical formulations
AssigneeMF Beauty Partners LLC
InventorJihoon P. Baek
Life of this patent
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Abstract
Topical formulations of L-ascorbic acid dissolved in a combination of a urea agent and a non-aqueous skin-compatible solvent are provided. The formulations are storage stable for an extended period of time without significant degradation of the L-ascorbic acid in the composition, are have desirable physical properties. The topical formulations can include high concentrations of the L-ascorbic acid. The topical formulations can include cinnamic acid or derivatives thereof as a penetration enhancer and stabilizing component of ascorbic acid. Topical compositions of this disclosure find use in treating or preventing a variety of cosmetic and/or dermatological conditions as well as to reduce the appearance of chronological and/or environmentally-caused skin aging.
Claims79
A storage stable topical composition comprising:
- a. 5% to 28% by weight ascorbic acid;
- b. 5% to 20% by weight of a urea agent;
- c. 0.1% to 5% by weight of a cinnamic acid or derivative thereof, and
- d. less than 10% by weight in total of one or more optional additional components;
- e. dissolved in a non-aqueous skin-compatible solvent comprising polyol, C(2-6) alkanediol, glycol ether, dimethyl ether, or a combination thereof, wherein the ascorbic acid is dissolved at a concentration (AA) that is above its maximum concentration in the solvent alone (X), and the urea is dissolved at a concentration that is at least (AA−X)*1.25.
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A process for stabilizing ascorbic acid for storage, the process comprising:
- combining:
- i. 1% to 20% by weight urea agent selected from urea, hydroxyethyl urea, and combination thereof,
- ii. 10% to 94% by weight of a non-aqueous skin-compatible solvent comprising C(3-6)polyol, ethoxydiglycol, dimethyl ether, or a combination thereof;
- iii. 0.1 to 5% or less of a cinnamic acid or derivatives thereof, and
- iv. optionally one or more additional agents;
- with
- v. 5% to 28% by weight ascorbic acid;
- thereby dissolving the ascorbic acid to produce storage stable, nonaqueous, single-phase clear liquid composition of ascorbic acid.
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Dependencies are inferred from the claim text.