Method for industrial production of spray-dried piperacillin-tazobactam powder

Abstract

Provided is a method for industrial production of spray-dried piperacillin-tazobactam powder, comprising the following steps: 1) preparing a mixed solution of piperacillin or a pharmaceutically acceptable salt thereof and tazobactam or a pharmaceutically acceptable salt thereof, and maintaining the pH value at 6.0-7.5; 2) adding a stabilizer into the solution obtained in the step 1) to give a mixed solution, wherein the stabilizer is selected from one or more of a carbohydrate, an amino acid, and a polyol; and 3) subjecting the mixed solution obtained in the step 2) to spray drying to give the spray-dried piperacillin-tazobactam powder.

Dependencies are inferred from the claim text.