Surface-modified doped titanium dioxide nanoparticles and uses
AssigneeThe Board of Regents of the University of Oklahoma
InventorsFernando Luis Esteban FLOREZ, Sharukh Soli KHAJOTIA, Adam Justin RONDINONE
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Abstract
A titanium dioxide (TiO2) composition and methods of use, the composition containing surface-modified doped TiO2 nanoparticles (sm-TiO2 NPs) disposed in a polymer matrix material, wherein each sm-TiO2 NP has an outer surface having a plurality of bifunctional linker molecules attached thereto and a plurality of protein molecules linked to the sm-TiO2 NP via the bifunctional linker molecules; and wherein the polymer matrix comprises a polymer precursor component.
Claims11
A method of treating a dental condition, comprising applying to a subject in need of such dental treatment a titanium dioxide (TiO2) composition comprising surface-modified doped TiO2 nanoparticles (sm-TiO2 NPs) disposed in a polymer matrix material, wherein each sm-TiO2 NP comprises
- an outer surface having a plurality of bifunctional linker molecules attached thereto, and
- a plurality of protein molecules linked to the sm-TiO2 NP via the bifunctional linker molecules, wherein the plurality of protein molecules which are linked to the sm-TiO2 NP via the bifunctional linker molecules bind to interfaces between the sm-TiO2 NPs and the polymer matrix material;
- and
- wherein the polymer matrix material comprises a polymer precursor component.
A method of treating a dental condition, comprising applying to a subject in need of such dental treatment a titanium dioxide (TiO2) composition, comprising surface-modified doped TiO2 nanoparticles (sm-TiO2 NPs) disposed in a polymer matrix material, wherein each sm-TiO2 NP comprises
- an outer surface having a plurality of bifunctional linker molecules attached thereto, and
- a plurality of protein molecules linked to the sm-TiO2 NP via the bifunctional linker molecules, wherein the plurality of protein molecules which are linked to the sm-TiO2 NP via the bifunctional linker molecules bind to interfaces between the sm-TiO2 NPs and the polymer matrix material;
- and
- wherein the polymer matrix material comprises a polymer precursor component;
- and wherein
- (a) the sm-TiO2 NPs comprise one or more dopants selected from the group consisting of N (nitrogen), Ag (silver), F (fluorine), P (phosphorus), and PO4 (phosphate),
- (b) the bifunctional linker molecule is a silane coupling agent selected from the group consisting of 3-(2-aminoethyl)-aminopropyltrimethoxysilane, heneicosafluorododecyltrichlorosilane, (3-aminopropyl) triethoxysilane, heptadecafluorodecyltrichlorosilane, octadecyltrichlorosilane, methyltrimethoxysilane, nonafluorohexyltrimethoxysilane, vinyltriethoxysilane, ethyltrimethoxysilane, propyltrimethoxysilane, trifluoropropyltrimethoxysilane, p-tolyltrimethoxysilane, cyanoethyltrimethoxysilane, aminopropyltrimethoxysilane, acetoxypropyltrimethoxylsilane, phenyltrimethoxysilane, chloropropyltrimethoxysilane, mercaptopropyltrimethoxysilane, glycidoxypropyltrimethoxysilane, γ-methacryloxypropyl trimethoxysilane, and vinyl trichlorosilane,
- (c) the polymeric matrix material is selected from the group consisting of acrylate resins, methacrylate resins, dimethacrylate ester resins, epoxy resins, polycarbonate, silicone, polyester, polyether, polyolefin, synthetic rubber, polyurethane, nylon, polystyrene, polyvinylaromatic, polyamide, polyimide, polyvinylhalide, polyphenylene oxide, polyketone, and copolymers and blends thereof, and
- (d) the polymer precursor component comprises at least one monomeric component selected from the group consisting of acrylates, methacrylates and dimethacrylates.
Dependencies are inferred from the claim text.