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US 2026/0185147 A1Published application
Imaging system hardware
Assignee10x Genomics, Inc.
InventorsAugusto Manuel Tentori, Rajiv Bharadwaj
Life of this patent
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Abstract
A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.
Claims30
A device comprising:
- a first substrate;
- a second substrate;
- a first support member comprising a first planar surface configured to support the first substrate;
- a first retaining mechanism comprising (i) a first recess formed in the first support member and configured to receive the first substrate and (ii) a first retaining member configured to apply a first force to one or more first lateral surfaces of the first substrate;
- a second support member comprising a second planar surface configured to support the second substrate;
- a second retaining mechanism comprising (i) a second recess formed in the second support member and configured to receive the second substrate and (ii) a second retaining member configured to apply a force to one or more second lateral surfaces of the second substrate;
- a rotating actuator operably connecting the first support member and the second support member;
- and
- a spacing member connected to the first support member or the second support member,
- wherein the first support member and the second support member have an open configuration and a closed configuration, wherein the rotating actuator is configured to allow relative movement of the first support member and the second support member to bring the first planar surface and the second planar surface toward one another from the open configuration to the closed configuration, and
- wherein the first support member, the second support member, the spacing member, and the rotating actuator are arranged such that, in the closed configuration:
- the first planar surface is parallel to and faces the second planar surface;
- and
- the spacing member contacts the first support member and the second support member such that the first planar surface is disposed at a distance from the second planar surface defined by the spacing member.
11 more elements
Dependencies are inferred from the claim text.