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US 2026/0185109 A1Published application
Systems and methods for quantification and manipulation of genome geometry for cellular reprogramming and computation
AssigneesNorthwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago
InventorsVadim Backman, Luay M. Almassalha, Igal G. Szleifer, Marcelo A. Carignano, Kyle Lauchlin MacQuarrie
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Abstract
Disclosed are compositions, systems, and methods of regulating gene transcription in a cell that include forming, stabilizing, and preventing decay of chromatin packing domains in the cell. Methods of forming chromatin packing domains include forming nascent chromatin packing domains that transition to mature packing domains.
Claims13
A method of regulating gene transcription in a cell comprising:
- forming one or more chromatin packing domain in the cell;
- stabilizing the one or more chromatin packing domain in the cell;
- and preventing decay of the stabilized chromatin packing domain.
Dependencies are inferred from the claim text.