Aptamers Against Clostridium Difficile
AssigneeLiv Process, Inc.
InventorsRonald J. Shannon, Michael McIntyre, David Bunka, Edward Barnes
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Abstract
Compositions comprising aptamers capable of specifically binding to a surface protein of Clostridium difficile spore are provided. A method for detecting, enriching, separating, and/or isolating Clostridium difficile spores is provided.
Claims21
-20. (canceled)
An aptamer, the aptamer comprising from position 22 to position 61 of the nucleotide sequence of SEQ ID NO:
- 6, wherein the aptamer has a binding affinity for CdeC surface protein of Clostridium difficile spore.
An aptamer, the aptamer comprising from position 22 to position 60 of the nucleotide sequence of SEQ ID NO:
- 10, wherein the aptamer has a binding affinity for CotA surface protein of Clostridium difficile spore.
An aptamer, the aptamer comprising from position 22 to position 61 of the nucleotide sequence of SEQ ID NO:
- 5, wherein the aptamer has a binding affinity for CotEC Chitinase surface protein of Clostridium difficile spore.
An aptamer, the aptamer comprising from position 22 to position 54 of the nucleotide sequence of SEQ ID NO:
- 13, wherein the aptamer has a binding affinity for CotE surface protein of Clostridium difficile spore.
Dependencies are inferred from the claim text.