Anti-idiotype antibodies and uses thereof
AssigneeMediterranea Theranostic S.R.L.
InventorSaverio ALBERTI
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Abstract
Chimeric antigen receptors (CARs) that are expressible by cells of the immune system such as T cells or NK cells (CAR-T and CAR-NK). These CARs comprise a fragment of scFv antibody directed against a specific antigen of tumor tissues, the tumor activated Trop-2 antigen wherein said activated Trop-2 is the Trop-2 molecule proteolytically cleaved between R87 and T88. The invention also involves the use of CAR constructs for use in anti-tumor cell therapy.
Claims18
An anti-idiotype antibody (anti-Id Ab) or antigen-binding fragment thereof, wherein the anti-Id Ab or antigen-binding fragment thereof specifically binds the idiotype region of an anti-Trop-2 antibody or an antibody fragment of the anti-Trop-2 antibody.
Dependencies are inferred from the claim text.