Anti-s100a8/a9 antibody and use thereof

A fully human antibody or antigen-binding fragment thereof, wherein the human antibody or antigen-binding fragment thereof comprises complementarity-determining regions (CDRs) comprising the following amino acid sequences according to a KABAT system:

• a heavy chain CDR1 comprising GX1TX2SX3X4X5X6X7, wherein X1 is F or Y, X2 is F, H, Y, or W, X3 is S or D, X4 is Y, H, or F, X5 is A or V, X6 is M, I, or L, and X7 is S or A;
• a heavy chain CDR2 comprising AISGX8GGSX9X10YX11X12SVKG, wherein X8 is S or H, X9 is T or H, X10 is Y, W, or F, X11 is A, H, V, or L, and X12 is D, A, or H;
• a heavy chain CDR3 comprising KX13RPX14RX15X16DX17, wherein X13 is Y, F, or H, X14 is S, T, or H, X15 is V or A, X16 is F, Y, H, or W, and X17 is S, A, F, C, H, or Y;
• a light chain CDR1 comprising SGDALX18DKX19X20X21, wherein X18 is G or H, X19 is Y or F, X20 is A or M, and X21 is S or A;
• a light chain CDR2 comprising X22X23X24X25RX26X27, wherein X22 is E or Q, X23 is D, H, or Q, X24 is S, A, or H, X25 is K, H, R, P, or N, X26 is P, Q, D, or N, and X27 is S, D, Y, or W;
• and
• a light chain CDR3 comprising X28SNDX29DX30X31W, wherein X28 is Q or D, X29 is A, V, I, or L, X30 is S or A, and X31 is V, Y, W, or R.