Use of modified hiv-1 for generating fully human antibodies
AssigneeUniversity of Massachusetts
InventorJeremy LUBAN
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Abstract
The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments thereof in a mammalian subject. The methods comprise administering a virus or virus-like particle to a mammal comprising heterologous immune cells and isolating a population of immunoglobulin-producing cells from the mammal, thereby producing the antibodies or antibody fragments thereof.
Claims21
1-50. (canceled)
An isolated nucleic acid comprising a nucleotide sequence at least about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, about 96%, about 97%, about 98%, or about 99% identity to SEQ ID NO:
- 1, wherein the isolated nucleic acid comprises at least one nucleotide sequence selected from the group consisting of SEQ ID NOs:
- 2, 3, and 4.
Dependencies are inferred from the claim text.