Engineered flavivirus envelope glycoprotein immunogenic compositions and methods of use
AssigneesUniversity of Maryland, Baltimore, University of Maryland, College Park
InventorsYuxing Li, Andrey Galkin, Alexander K. Andrianov, Yimeng Wang
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Abstract
The present invention provides polypeptides, and polypeptide dimers, comprising a modified flavivirus envelope E polypeptide, wherein the modified flavivirus envelope E polypeptide comprises i) a cysteine residue in a fusion loop epitope of ectodomain DII; and ii) a cysteine residue in ectodomain DI located in an N-terminal portion of the polypeptide, nucleic acids, vectors, host cells, and pharmaceutical compositions comprising the same, and methods of inducing an immune response in subjects by administering the pharmaceutical compositions of the invention.
Claims24
A polypeptide comprising a modified flavivirus envelope E polypeptide, wherein the modified flavivirus envelope E polypeptide comprises i) a cysteine residue in a fusion loop epitope of ectodomain DII;
- and ii) a cysteine residue in ectodomain DI located in an N-terminal portion of the polypeptide.
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Dependencies are inferred from the claim text.