Pyridazinones and methods of use thereof

A compound of Formula (II), or a tautomer or a pharmaceutically acceptable salt thereof,

• wherein
• R1 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, heteroaryl, —OH, —CN, -cycloalkyl, —O-alkyl, —O-cycloalkyl, —O-aryl, -aryl-O-aryl —CF3, —C(H)F2, alkylene-CF3, alkylene-C(H)F2, —SO2-alkyl, and —O-alkylene-O-alkyl;
• R2 is -heterocyclyl-L-R4, wherein the heterocyclyl of -heterocyclyl-L-R4 is selected from the group consisting of
• each of which is optionally substituted with one or two substituents selected from group selected from alkyl, halogen, hydroxyl, carbonyl, thiocarbonyl, alkoxy, phosphoryl, phosphate, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, alkylthio, sulfate, sulfonate, sulfamoyl, sulfonamido, and sulfonyl,
• R4 is absent or selected from the group consisting of alkyl, cycloalkyl, aryl, alkylene-aryl, alkylene-heteroaryl, heteroaryl, heterocyclyl, —C(O)N(R5)2, and CF3;
• R5 is independently H or alkyl;
• R6 is selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, alkylene-aryl, —C(O)N(R5)2, and CF3;
• R7 is H, alkyl, —O-aryl, —O-alkyl, or cycloalkyl;
• L is absent or selected from the group consisting of methylene, —C(O)—, —SO2—, —CH2N(Me)-, —N(R5)(R6)—, —C(R5)(R6)—, and —O—R6;
• one and only one of R1 and R2 is -heterocyclyl-L-R4 or -heteroaryl-L-R4;
• and
• n is one, two, three, or four.