Heterocyclic compounds, preparation methods and uses thereof

A compound of Formula I, or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 are an optionally substituted C3-10 carbocyclyl, an optionally substituted 4-10 membered heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• R2 is hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 heteroalkyl, or a nitrogen protecting group;
• or
• R1 and R2, together with the intervening C, C, C, and N atoms, are joined to form a 5-14 membered heterocyclyl, which is optionally substituted;
• R3 is RA, ORA, SRA, S(O)RA, S(O)2RA, CORA, COORA, CN, NHRA, CONHRA, S(O)2NHRA, S(O)(NH)RA, NHCORA, NHS(O)2RA, or NO2, wherein RA is independently hydrogen, halogen, CN, OH, an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C2-6 alkynyl, an optionally substituted C1-6 heteroalkyl, an optionally substituted C1-6 haloalkyl, an optionally substituted C30.10 carbocyclyl, an optionally substituted 4-10 membered heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• X1 is N or CR4, wherein R4 is H, F, Cl, OH, NH2, CN, CD3, CF3, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 heteroalkyl, or an optionally substituted C3-6 cycloalkyl;
• X2 is N or CR5, wherein R5 is H, F, Cl, OH, NH2, CN, CD3, CF3, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 heteroalkyl, or an optionally substituted C3-6 cycloalkyl;
• X3 is N or CR6, wherein R6 is H, F, Cl, OH, NH2, CN, CD3, CF3, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 heteroalkyl, or an optionally substituted C3-6 cycloalkyl;
• or
• R5 and R6, together with the intervening C and C atoms, are joined to form a 5-8 membered heteroaryl, which is optionally substituted;
• is an optionally substituted C3-10 carbocyclic ring, an optionally substituted 4-10 membered heterocyclic ring, an optionally substituted aromatic ring containing 0, 1, 2, or 3 heteroatoms independently selected from N, O, and S;
• RS at each occurrence is independently RT, ORT, SRT, NHRT, CORT, COORT, CONHRT, NHCORT, CN, or NO2, wherein RT is independently hydrogen, halogen (e.g. F, Cl, or Br), CN, OH, an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C2-6 alkynyl, an optionally substituted C1-6 heteroalkyl, an optionally substituted C1-6 haloalkyl, an optionally substituted C3-10 carbocyclyl, an optionally substituted 4-10 membered heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• and
• n is 0, 1, 2, or 3.